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Synergen Inc il-1 ra
Il 1 Ra, supplied by Synergen Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/il-1+ra/il+1+ra/us12173065-605-28-33
Average 90 stars, based on 1 article reviews
il-1 ra - by Bioz Stars, 2026-10
90/100 stars

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Recombinant:

Article Title: In vitro effects of Clostridium difficile toxins on hepatocytes.
Article Snippet: Background.. Clostridium difficile infections are associated with development of the systemic inflammatory response, including the production of hepatic acute phase proteins.. Lipopolysaccharide (LPS) directly stimulates the production of at least one of these proteins, a 23-kDa acute phase protein (the LPSinduced protein, or LIP) by murine hepatocytes in vitro.

Article Title: TNF-α binding molecules
Article Snippet: 36, 1223); Anti-Tac (humanized anti-IL-2R.alpha; Protein Design Labs/Roche); IL-4 (anti-inflammatory cytokine; DNAX/Schering); IL-10 (SCH 52000; recombinant IL-10, anti-inflammatory cytokine; DNAX/Schering); IL-10 and/or IL-4 agonists (e.g., agonist antibodies); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); TNF-bp/s-TNFR (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Article Title: Fusion proteins comprising extracellular domain of human CD22
Article Snippet: 44, 235A); 55 kdTNFR-IgG (55 kD TNF receptor-IgG fusion protein; Hoffmann-LaRoche); IL-10; IL-4; and IL-10 and/or IL-4 agonists (e.g., agonist antibodies);); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); TNF-bp/s-TNFR (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Article Title: Fusion proteins comprising extracellular domain of human CD22
Article Snippet: 36, 1223); Anti-Tac (humanized anti-IL-2Ra; Protein Design Labs/Roche); IL-3 (anti-inflammatory cytokine; DNAS/Schering); IL-10 (SCH 52000; recombinant IL-10, anti-inflammatory cytokine; DNAX/Schering); IL-4; IL-10 and/or IL-4 agonists (e.g., agonist antibodies); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); TNF-bp/s-TNFR (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Article Title: Effects of cytokine antagonists on the hepatic acute-phase response.
Article Snippet: 6), and, to a lesser extent, by glucocorticoid hormones Endotoxin-induced hepatic acute-phase protein syn[3–9].. Most stimuli which trigger the acute phase rethesis has been thought to be primarily regulated sponse in vivo, such as bacterial endotoxin or lipopolythrough cytokines such as interleukin-1 (IL-1) and insaccharide (LPS), are thought to act through these meterleukin-6 (IL-6).. Previously, it was found that a 23diators. kDa murine acute-phase protein, the lipopolysacchaIn previous studies of the hepatic acute-phase reride (LPS)-induced protein (LIP), was synthesized folsponse, we observed that a 23-kDa acute-phase protein lowing treatment of hepatocytes in vitro with LPS. was induced after treatment of primary murine hepatoSince this protein was also induced by IL-1 and IL-6, cyte cultures with cytokines obtained from LPS-stimuthe present studies were undertaken to determine if lated Kupffer cells or peritoneal macrophages, and also the effect of endotoxin was mediated through these by purified preparations of IL-1 [10].

Article Title: Method of treating a tumor necrosis factor α (TNFα)-related disorder by using an induction dosing regimen of adalimumab
Article Snippet: 36, 1223); Anti-Tac (humanized anti-IL-2Ra; Protein Design Labs/Roche); IL-4 (anti-inflammatory cytokine; DNAX/Schering); IL-10 (SCH 52000; recombinant IL-10, anti-inflammatory cytokine; DNAX/Schering); IL-4; IL-10 and/or IL-4 agonists (e. g., agonist antibodies); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); anakinra (Kineret@/Amgen); TNF-bp/s-TNF (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Binding Assay:

Article Title: In vitro effects of Clostridium difficile toxins on hepatocytes.
Article Snippet: Background.. Clostridium difficile infections are associated with development of the systemic inflammatory response, including the production of hepatic acute phase proteins.. Lipopolysaccharide (LPS) directly stimulates the production of at least one of these proteins, a 23-kDa acute phase protein (the LPSinduced protein, or LIP) by murine hepatocytes in vitro.

Article Title: TNF-α binding molecules
Article Snippet: 36, 1223); Anti-Tac (humanized anti-IL-2R.alpha; Protein Design Labs/Roche); IL-4 (anti-inflammatory cytokine; DNAX/Schering); IL-10 (SCH 52000; recombinant IL-10, anti-inflammatory cytokine; DNAX/Schering); IL-10 and/or IL-4 agonists (e.g., agonist antibodies); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); TNF-bp/s-TNFR (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Article Title: Fusion proteins comprising extracellular domain of human CD22
Article Snippet: 44, 235A); 55 kdTNFR-IgG (55 kD TNF receptor-IgG fusion protein; Hoffmann-LaRoche); IL-10; IL-4; and IL-10 and/or IL-4 agonists (e.g., agonist antibodies);); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); TNF-bp/s-TNFR (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Article Title: Fusion proteins comprising extracellular domain of human CD22
Article Snippet: 36, 1223); Anti-Tac (humanized anti-IL-2Ra; Protein Design Labs/Roche); IL-3 (anti-inflammatory cytokine; DNAS/Schering); IL-10 (SCH 52000; recombinant IL-10, anti-inflammatory cytokine; DNAX/Schering); IL-4; IL-10 and/or IL-4 agonists (e.g., agonist antibodies); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); TNF-bp/s-TNFR (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Article Title: Effects of cytokine antagonists on the hepatic acute-phase response.
Article Snippet: 6), and, to a lesser extent, by glucocorticoid hormones Endotoxin-induced hepatic acute-phase protein syn[3–9].. Most stimuli which trigger the acute phase rethesis has been thought to be primarily regulated sponse in vivo, such as bacterial endotoxin or lipopolythrough cytokines such as interleukin-1 (IL-1) and insaccharide (LPS), are thought to act through these meterleukin-6 (IL-6).. Previously, it was found that a 23diators. kDa murine acute-phase protein, the lipopolysacchaIn previous studies of the hepatic acute-phase reride (LPS)-induced protein (LIP), was synthesized folsponse, we observed that a 23-kDa acute-phase protein lowing treatment of hepatocytes in vitro with LPS. was induced after treatment of primary murine hepatoSince this protein was also induced by IL-1 and IL-6, cyte cultures with cytokines obtained from LPS-stimuthe present studies were undertaken to determine if lated Kupffer cells or peritoneal macrophages, and also the effect of endotoxin was mediated through these by purified preparations of IL-1 [10].

Article Title: Method of treating a tumor necrosis factor α (TNFα)-related disorder by using an induction dosing regimen of adalimumab
Article Snippet: 36, 1223); Anti-Tac (humanized anti-IL-2Ra; Protein Design Labs/Roche); IL-4 (anti-inflammatory cytokine; DNAX/Schering); IL-10 (SCH 52000; recombinant IL-10, anti-inflammatory cytokine; DNAX/Schering); IL-4; IL-10 and/or IL-4 agonists (e. g., agonist antibodies); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); anakinra (Kineret@/Amgen); TNF-bp/s-TNF (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Injection:

Article Title: In vitro effects of Clostridium difficile toxins on hepatocytes.
Article Snippet: Background.. Clostridium difficile infections are associated with development of the systemic inflammatory response, including the production of hepatic acute phase proteins.. Lipopolysaccharide (LPS) directly stimulates the production of at least one of these proteins, a 23-kDa acute phase protein (the LPSinduced protein, or LIP) by murine hepatocytes in vitro.

Article Title: TNF-α binding molecules
Article Snippet: 36, 1223); Anti-Tac (humanized anti-IL-2R.alpha; Protein Design Labs/Roche); IL-4 (anti-inflammatory cytokine; DNAX/Schering); IL-10 (SCH 52000; recombinant IL-10, anti-inflammatory cytokine; DNAX/Schering); IL-10 and/or IL-4 agonists (e.g., agonist antibodies); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); TNF-bp/s-TNFR (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Article Title: Fusion proteins comprising extracellular domain of human CD22
Article Snippet: 44, 235A); 55 kdTNFR-IgG (55 kD TNF receptor-IgG fusion protein; Hoffmann-LaRoche); IL-10; IL-4; and IL-10 and/or IL-4 agonists (e.g., agonist antibodies);); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); TNF-bp/s-TNFR (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Article Title: Fusion proteins comprising extracellular domain of human CD22
Article Snippet: 36, 1223); Anti-Tac (humanized anti-IL-2Ra; Protein Design Labs/Roche); IL-3 (anti-inflammatory cytokine; DNAS/Schering); IL-10 (SCH 52000; recombinant IL-10, anti-inflammatory cytokine; DNAX/Schering); IL-4; IL-10 and/or IL-4 agonists (e.g., agonist antibodies); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); TNF-bp/s-TNFR (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Article Title: Effects of cytokine antagonists on the hepatic acute-phase response.
Article Snippet: 6), and, to a lesser extent, by glucocorticoid hormones Endotoxin-induced hepatic acute-phase protein syn[3–9].. Most stimuli which trigger the acute phase rethesis has been thought to be primarily regulated sponse in vivo, such as bacterial endotoxin or lipopolythrough cytokines such as interleukin-1 (IL-1) and insaccharide (LPS), are thought to act through these meterleukin-6 (IL-6).. Previously, it was found that a 23diators. kDa murine acute-phase protein, the lipopolysacchaIn previous studies of the hepatic acute-phase reride (LPS)-induced protein (LIP), was synthesized folsponse, we observed that a 23-kDa acute-phase protein lowing treatment of hepatocytes in vitro with LPS. was induced after treatment of primary murine hepatoSince this protein was also induced by IL-1 and IL-6, cyte cultures with cytokines obtained from LPS-stimuthe present studies were undertaken to determine if lated Kupffer cells or peritoneal macrophages, and also the effect of endotoxin was mediated through these by purified preparations of IL-1 [10].

Article Title: Method of treating a tumor necrosis factor α (TNFα)-related disorder by using an induction dosing regimen of adalimumab
Article Snippet: 36, 1223); Anti-Tac (humanized anti-IL-2Ra; Protein Design Labs/Roche); IL-4 (anti-inflammatory cytokine; DNAX/Schering); IL-10 (SCH 52000; recombinant IL-10, anti-inflammatory cytokine; DNAX/Schering); IL-4; IL-10 and/or IL-4 agonists (e. g., agonist antibodies); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); anakinra (Kineret@/Amgen); TNF-bp/s-TNF (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Saline:

Article Title: In vitro effects of Clostridium difficile toxins on hepatocytes.
Article Snippet: Background.. Clostridium difficile infections are associated with development of the systemic inflammatory response, including the production of hepatic acute phase proteins.. Lipopolysaccharide (LPS) directly stimulates the production of at least one of these proteins, a 23-kDa acute phase protein (the LPSinduced protein, or LIP) by murine hepatocytes in vitro.

Article Title: TNF-α binding molecules
Article Snippet: 36, 1223); Anti-Tac (humanized anti-IL-2R.alpha; Protein Design Labs/Roche); IL-4 (anti-inflammatory cytokine; DNAX/Schering); IL-10 (SCH 52000; recombinant IL-10, anti-inflammatory cytokine; DNAX/Schering); IL-10 and/or IL-4 agonists (e.g., agonist antibodies); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); TNF-bp/s-TNFR (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Article Title: Fusion proteins comprising extracellular domain of human CD22
Article Snippet: 44, 235A); 55 kdTNFR-IgG (55 kD TNF receptor-IgG fusion protein; Hoffmann-LaRoche); IL-10; IL-4; and IL-10 and/or IL-4 agonists (e.g., agonist antibodies);); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); TNF-bp/s-TNFR (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Article Title: Fusion proteins comprising extracellular domain of human CD22
Article Snippet: 36, 1223); Anti-Tac (humanized anti-IL-2Ra; Protein Design Labs/Roche); IL-3 (anti-inflammatory cytokine; DNAS/Schering); IL-10 (SCH 52000; recombinant IL-10, anti-inflammatory cytokine; DNAX/Schering); IL-4; IL-10 and/or IL-4 agonists (e.g., agonist antibodies); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); TNF-bp/s-TNFR (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Article Title: Effects of cytokine antagonists on the hepatic acute-phase response.
Article Snippet: 6), and, to a lesser extent, by glucocorticoid hormones Endotoxin-induced hepatic acute-phase protein syn[3–9].. Most stimuli which trigger the acute phase rethesis has been thought to be primarily regulated sponse in vivo, such as bacterial endotoxin or lipopolythrough cytokines such as interleukin-1 (IL-1) and insaccharide (LPS), are thought to act through these meterleukin-6 (IL-6).. Previously, it was found that a 23diators. kDa murine acute-phase protein, the lipopolysacchaIn previous studies of the hepatic acute-phase reride (LPS)-induced protein (LIP), was synthesized folsponse, we observed that a 23-kDa acute-phase protein lowing treatment of hepatocytes in vitro with LPS. was induced after treatment of primary murine hepatoSince this protein was also induced by IL-1 and IL-6, cyte cultures with cytokines obtained from LPS-stimuthe present studies were undertaken to determine if lated Kupffer cells or peritoneal macrophages, and also the effect of endotoxin was mediated through these by purified preparations of IL-1 [10].

Article Title: Method of treating a tumor necrosis factor α (TNFα)-related disorder by using an induction dosing regimen of adalimumab
Article Snippet: 36, 1223); Anti-Tac (humanized anti-IL-2Ra; Protein Design Labs/Roche); IL-4 (anti-inflammatory cytokine; DNAX/Schering); IL-10 (SCH 52000; recombinant IL-10, anti-inflammatory cytokine; DNAX/Schering); IL-4; IL-10 and/or IL-4 agonists (e. g., agonist antibodies); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); anakinra (Kineret@/Amgen); TNF-bp/s-TNF (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Concentration Assay:

Article Title: In vitro effects of Clostridium difficile toxins on hepatocytes.
Article Snippet: Background.. Clostridium difficile infections are associated with development of the systemic inflammatory response, including the production of hepatic acute phase proteins.. Lipopolysaccharide (LPS) directly stimulates the production of at least one of these proteins, a 23-kDa acute phase protein (the LPSinduced protein, or LIP) by murine hepatocytes in vitro.

Article Title: TNF-α binding molecules
Article Snippet: 36, 1223); Anti-Tac (humanized anti-IL-2R.alpha; Protein Design Labs/Roche); IL-4 (anti-inflammatory cytokine; DNAX/Schering); IL-10 (SCH 52000; recombinant IL-10, anti-inflammatory cytokine; DNAX/Schering); IL-10 and/or IL-4 agonists (e.g., agonist antibodies); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); TNF-bp/s-TNFR (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Article Title: Fusion proteins comprising extracellular domain of human CD22
Article Snippet: 44, 235A); 55 kdTNFR-IgG (55 kD TNF receptor-IgG fusion protein; Hoffmann-LaRoche); IL-10; IL-4; and IL-10 and/or IL-4 agonists (e.g., agonist antibodies);); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); TNF-bp/s-TNFR (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Article Title: Fusion proteins comprising extracellular domain of human CD22
Article Snippet: 36, 1223); Anti-Tac (humanized anti-IL-2Ra; Protein Design Labs/Roche); IL-3 (anti-inflammatory cytokine; DNAS/Schering); IL-10 (SCH 52000; recombinant IL-10, anti-inflammatory cytokine; DNAX/Schering); IL-4; IL-10 and/or IL-4 agonists (e.g., agonist antibodies); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); TNF-bp/s-TNFR (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.

Article Title: Effects of cytokine antagonists on the hepatic acute-phase response.
Article Snippet: 6), and, to a lesser extent, by glucocorticoid hormones Endotoxin-induced hepatic acute-phase protein syn[3–9].. Most stimuli which trigger the acute phase rethesis has been thought to be primarily regulated sponse in vivo, such as bacterial endotoxin or lipopolythrough cytokines such as interleukin-1 (IL-1) and insaccharide (LPS), are thought to act through these meterleukin-6 (IL-6).. Previously, it was found that a 23diators. kDa murine acute-phase protein, the lipopolysacchaIn previous studies of the hepatic acute-phase reride (LPS)-induced protein (LIP), was synthesized folsponse, we observed that a 23-kDa acute-phase protein lowing treatment of hepatocytes in vitro with LPS. was induced after treatment of primary murine hepatoSince this protein was also induced by IL-1 and IL-6, cyte cultures with cytokines obtained from LPS-stimuthe present studies were undertaken to determine if lated Kupffer cells or peritoneal macrophages, and also the effect of endotoxin was mediated through these by purified preparations of IL-1 [10].

Article Title: Method of treating a tumor necrosis factor α (TNFα)-related disorder by using an induction dosing regimen of adalimumab
Article Snippet: 36, 1223); Anti-Tac (humanized anti-IL-2Ra; Protein Design Labs/Roche); IL-4 (anti-inflammatory cytokine; DNAX/Schering); IL-10 (SCH 52000; recombinant IL-10, anti-inflammatory cytokine; DNAX/Schering); IL-4; IL-10 and/or IL-4 agonists (e. g., agonist antibodies); IL-1 RA (IL-1 receptor antagonist; Synergen/Amgen); anakinra (Kineret@/Amgen); TNF-bp/s-TNF (soluble TNF binding protein; see e.g., Arthritis & Rheumatism (1996) Vol.



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(a) The plantar incision induced a reduction in mechanical threshold against von Frey stimulation. Intrathecal <t>IL-1RA</t> administration significantly inhibited the reduction of the mechanical threshold for 6 h after the treatment. (b) The plantar incision induced a reduction in latency time against thermal stimulation. Intrathecal IL-1RA administration significantly inhibited reduction in the thermal pain latency for 6 h after the treatment. Data were analyzed by repeated measures two-way ANOVA, with Bonferroni’s multiple comparison test comparing pre- and post-treatment time points for each group ( # p < .05, ## p < .01, ### p < .001), and Bonferroni’s multiple comparison test comparing both groups at each time point (* p < .05, ** p < .01, *** p < .001). The data in the graphs are presented as the mean ± SEM ( n = 6 in each group). i.t.: intrathecal administration. Intrathecal administration of IL-1β induced reduction of the mechanical threshold against von Frey stimulation (c) and reduction of latency time against thermal stimulation (d). Data were analyzed by repeated measures two-way ANOVA, with Bonferroni’s multiple comparison test comparing pre- and post-treatment time points for each group ( # p < .05, ## p < .01) and Bonferroni’s multiple comparison test comparing both groups at each time point (* p < .05, ** p < .01). The data in the graphs are presented as the mean ± SEM ( n = 6 in each group).
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Image Search Results


Characteristics of the studies.

Journal: Journal of Clinical Medicine

Article Title: Efficacy of Anti-Interleukin-1 Therapeutics in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials from the Years 2000 to 2023

doi: 10.3390/jcm13102859

Figure Lengend Snippet: Characteristics of the studies.

Article Snippet: 8 , Chevalier 2009 [ ] , Muliticentre RCT , France , Amgen Inc , Anakinra (IL-1 Ras) , Single IA , 12 , 50 mg , 1 , 34 , 69.

Techniques: Control

(a) The plantar incision induced a reduction in mechanical threshold against von Frey stimulation. Intrathecal IL-1RA administration significantly inhibited the reduction of the mechanical threshold for 6 h after the treatment. (b) The plantar incision induced a reduction in latency time against thermal stimulation. Intrathecal IL-1RA administration significantly inhibited reduction in the thermal pain latency for 6 h after the treatment. Data were analyzed by repeated measures two-way ANOVA, with Bonferroni’s multiple comparison test comparing pre- and post-treatment time points for each group ( # p < .05, ## p < .01, ### p < .001), and Bonferroni’s multiple comparison test comparing both groups at each time point (* p < .05, ** p < .01, *** p < .001). The data in the graphs are presented as the mean ± SEM ( n = 6 in each group). i.t.: intrathecal administration. Intrathecal administration of IL-1β induced reduction of the mechanical threshold against von Frey stimulation (c) and reduction of latency time against thermal stimulation (d). Data were analyzed by repeated measures two-way ANOVA, with Bonferroni’s multiple comparison test comparing pre- and post-treatment time points for each group ( # p < .05, ## p < .01) and Bonferroni’s multiple comparison test comparing both groups at each time point (* p < .05, ** p < .01). The data in the graphs are presented as the mean ± SEM ( n = 6 in each group).

Journal: Molecular Pain

Article Title: Rapid cleavage of IL-1β in DRG neurons produces tissue injury-induced pain hypersensitivity

doi: 10.1177/17448069241285357

Figure Lengend Snippet: (a) The plantar incision induced a reduction in mechanical threshold against von Frey stimulation. Intrathecal IL-1RA administration significantly inhibited the reduction of the mechanical threshold for 6 h after the treatment. (b) The plantar incision induced a reduction in latency time against thermal stimulation. Intrathecal IL-1RA administration significantly inhibited reduction in the thermal pain latency for 6 h after the treatment. Data were analyzed by repeated measures two-way ANOVA, with Bonferroni’s multiple comparison test comparing pre- and post-treatment time points for each group ( # p < .05, ## p < .01, ### p < .001), and Bonferroni’s multiple comparison test comparing both groups at each time point (* p < .05, ** p < .01, *** p < .001). The data in the graphs are presented as the mean ± SEM ( n = 6 in each group). i.t.: intrathecal administration. Intrathecal administration of IL-1β induced reduction of the mechanical threshold against von Frey stimulation (c) and reduction of latency time against thermal stimulation (d). Data were analyzed by repeated measures two-way ANOVA, with Bonferroni’s multiple comparison test comparing pre- and post-treatment time points for each group ( # p < .05, ## p < .01) and Bonferroni’s multiple comparison test comparing both groups at each time point (* p < .05, ** p < .01). The data in the graphs are presented as the mean ± SEM ( n = 6 in each group).

Article Snippet: Mice were randomly assigned to saline and IL-1 RA (500 ng/5 μL, diluted in saline, Recombinant Human IL-1ra/IL-1F3, #280-RA/CF, R&D Systems, Inc. Minneapolis, MN 55413) groups ( n = 6 per group).

Techniques: Comparison